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See Full Prescribing Information for Fluzone® High-Dose Quadrivalent (Influenza Vaccine), Flublok® Quadrivalent (Influenza Vaccine), Fluzone® Quadrivalent (Influenza Vaccine)
the threat of influenza is formidable
but now so are your vaccine options

Only 2 Influenza Vaccines Have Been Proven to Prevent More Cases of Influenza versus Standard-Dose Vaccine Comparators in older adults1-4

According to a head-to-head randomized controlled efficacy trial among adults 65+ years of age, FLUZONE HIGH-DOSE (INFLUENZA VACCINE) provided 24% (95%, CI: 10-37) better protection against influenza due to lab-confirmed circulating strain compared with standard-dose Fluzone (Influenza vaccine).1,3,a

Based on data from Fluzone High-Dose, solicited injection site reactions and systemic adverse reactions were slightly more frequent after vaccination with Fluzone High-Dose compared with a standard-dose vaccine.1

a The efficacy of the trivalent formulation is relevant to Fluzone High-Dose Quadrivalent since both vaccines are manufactured according to the same process and have overlapping compositions.

A QUADRIVALENT FORMULATION OF FLUZONE HIGH-DOSE

  • Helps to protect against 2 influenza A strains and BOTH INFLUENZA B LINEAGES that co-circulate unpredictably each season1
  • 4X THE AMOUNT OF ANTIGEN of standard-dose quadrivalent inactivated influenza vaccine5
  • 0.7-mL dose for intramuscular injection1
  • Similar safety profile to Fluzone High-Dose, the trivalent formulation1

According to a head-to-head randomized controlled trial among adults 50+ years of age, FLUBLOK QUADRIVALENT was proven to provide 30% (95% CI: 10-47) better protection against influenza due to PCR-confirmed strains versus a standard-dose quadrivalent inactivated influenza vaccine.1,2

In this randomized controlled trial, the most common local and systemic adverse reactions to Flublok Quadrivalent included tenderness and pain at the injection site, headache, and fatigue.2

Flublok Quadrivalent has a similar safety profile compared with a standard-dose inactivated influenza vaccine.2

AN INFLUENZA VACCINE WITH A UNIQUE COMPOSITION

  • 3X more hemagglutinin antigen versus a standard-dose quadrivalent inactivated influenza vaccine6
  • Made with RECOMBINANT DNA TECHNOLOGY4:
    • Eliminates the need to grow influenza virus during manufacturing, which ensures hemagglutinin antigen cannot adapt or mutate
    • Avoids changes in hemagglutinin antigen structure that can lead to reduced vaccine effectiveness


    Fluzone Quadrivalent for patients 6+ months
    • 4-strain defense that helps protect patients 6+ months7

    Fluzone Quadrivalent, Flublok Quadrivalent, and Fluzone High-Dose Quadrivalent are vaccines indicated for active immunization against disease caused by influenza A subtype viruses and influenza type B viruses contained in the vaccine. Fluzone Quadrivalent is approved for use in persons 6 months of age and older. Flublok Quadrivalent is approved for use in persons 18 years of age and older. Fluzone High-Dose Quadrivalent is approved for use in persons 65 years of age and older.

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